Advanced Analytical Testing
Bring your cannabis product vision to a reality
Bring your cannabis product vision to a reality
This test is used for general identification of sample compounds by determining functional groups within each compound. It can be used to characterize different cannabis cultivars to help you match the right material to the optimal conditions for production.
Read this article to learn how IR can support your production processes.
This test measures the heat transfer during chemical reactions and can help determine the kinetics of a reaction. Calorimetry is an integral part of process scale-up and chemical engineering. Alternatively, in conjunction with other tests, a comparative study of the amphipathic interactions of your products with biological membranes can be determined.
This test determines the temperature at which a compound moves from the solid to the liquid state. Understanding this element of the product’s behavior can assist with product characterization, manufacturing, and packaging. Using the proper temperatures for packaging materials that get heated and change physical state, such as lip balms, is critical for maintaining the integrity and intended effects of the product.
This test characterizes, quantifies, and assesses the purity of single compounds or mixtures in solutions or solid states. The results produce a chemical fingerprint of the composition of your product, which can identify unknowns in formulations and offer insights into possible future improvements of the product.
This test uses high-resolution Liquid Chromatography (LC) and Gas Chromatography (GC) instruments to reveal all the metabolites in your product. It can help determine sample purity and consistency of compounds beyond just THC and CBD. Possible avenues of exploration include taxonomy of chemovars, plant cultivation optimization, and assessment of cannabis-based sources of bioactivity in medicine.
This test captures gasses and aerosols formed during smoking and vaping. Coupled with an analysis on a Gas Chromatography Mass Spectroscopy (GCMS) instrument, the results identify and quantify compounds present within the formed aerosols. We can support your toxicological studies, improve the safety of your products, and help tailor the smoking experiences for your consumers.
This test measures the size and size distribution of particles in a sample. This is an important test used in quality control and product development. It can be used to establish the particle size in powders, like CBD isolate, where exact sizing is important for bioavailability. Particle sizing also supports research projects in extraction optimization and pre-roll manufacturing.
Read this article to learn how to optimize extraction processes with particle sizing.
These tests provide information about the crystal structure, chemical composition, and the physical properties of your product.
SINGLE CRYSTAL METHOD:
Results offer detailed information on the atomic structure of compounds. Single crystals are required for a successful analysis and must be provided by the client.
POWDER METHOD (PXRD):
Instead of single crystals, powder samples are probed for information on atomic structure, identification, and sample purity. Powder samples can be mixtures and thus are easier to create than single crystals, but the structural information provided in the results is less comprehensive that when using the single crystal method.
This process docks ligands into a protein model, resulting in protein-ligand complexes.
(With Schrodinger Glide): analysis of provided or publicly available crystal structure into defined binding pocket with top 5 poses (if applicable) reported, results provided in .pdb format.
(With Schrodinger Prime): analysis of provided or publicly available crystal structure into defined binding pocket with top 5 poses (if applicable) reported, results provided in .pdb format
NANOPARTICLE SIZING, PDI:
Using dynamic light scattering (DLS), nanometer particle size and polydispersity (PDI) of an emulsion or nanoparticle is determined. For beverages that incorporate emulsions and also nanoparticle drug product development, these results can be used to understand the impact of mixing variables (eg. mixing speed, excipient ratios) on the size and quality of resulting particles.
A nanoemulsion or nanoparticle that does not change over time is defined as stable or as having a long shelf-life. Minimal differences in size and quality are desired and indicative of a well balanced nanoparticle formulation, and one that will be able to be stored without change for a period of time. Stability is tested over 1 month with 8 timepoints.
Nanoparticles have the potential to stabilize the compounds they encapsulate. This test helps determine if the nanoparticles maintain the potency of the original compounds over time which is important in the case of cannabinoids that change under light, pH and oxidation. Stability is tested over 1 month with 8 timepoints.
NANOPARTICLE DISSOLUTION PROFILE:
Dissolution is a bench test that quantifies the release of active ingredients from a particle in an environment mimicking physiological conditions (temperature, pH). The dissolution profile of a product can help predict how the active ingredients will reach the blood stream, or how different formulations impart unique active ingredient release profiles (eg. fast-acting vs long-lasting). Sample is tested over 8 timepoints.
NANOPARTICLE ENCAPSULATION EFFICIENCY:
Encapsulation efficiency is used to understand how much active ingredient (cannabinoids) is found within each nanoparticle and how much is lost in the process of formulating. Process losses due to handling, container adhesion, surfactant make-up and excipient concentrations all have the potential to reduce the amount of cannabinoids in the particle.